We are interested in the function of cytokines in the immune system during health and disease. We study how cytokines coordinate immune homeostasis and responses, and how they stimulate various immune cells in vitro and in different models of cancer, inflammatory and autoimmune disease, as well as allograft rejection. To this end, we generate and characterize natural versus modified cytokine formulations, including cytokine-antibody complexes, in order to better understand cytokine biology and improve cytokine-directed immunotherapy.
Cytokines, especially those sharing the common gamma chain cytokine receptor such as IL-2, play a central role in the immune system.
Monoclonal antibody (mAb) complexes
By combining IL-2 with anti-IL-2 mAb to specific complexes, IL-2 can preferentially stimulate the desired effect on the immune system.
Therapeutic use of cytokines
Cytokines and particularly cytokine/mAb complexes can be used for immunotherapy in cancer, inflammatory or autoimmune diseases.